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Dissolution Enhancement of Poorly Soluble Drugs by Using Complexation Technique – A Review

By Saravana Kumar K, Sushma M and Prasanna Raju Y


Orally administered drugs completely absorb only when they show fair solubility in gastric medium and shows good bioavailability. The solubility properties of drug play an important role in the process of formulation developments. Problem of solubility can be solved by different approaches. Each approach suffers with some limitations and advantages. Among all, complexation techinque has been employed to improve the solubility of poorly water soluble drugs. sophistication has to find its way in the area of excepients. One such versatile adjuvant, tailored with the help of advances in technology is cyclodextrin. Such cyclodextrin can interact with appropriate size drug molecules which lead to the formulation of inclusion complexes. A comprehensive literature survey was made collect the rightful utilization of cyclodextrins as complexing, solubility enhancing agents. In present review,an attempt was made to discuss various complexation techinques and highlight the applications with these approaches. Key Words: Cyclodextrins, solubility, dissolution, inclusion complexation, excipients

Year: 2013
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