1. Analysis of the activity of single neurones in the gustatory pathways in primates (cynomolgus monkeys) shows that the tuning of neurones to the four prototypical stimuli 1-Omoll " 1 glucose, 1-Omoll " 1 NaCl, 0-OOlmoll " 1 quinine-HC1 and 0-01 mol I " 1 HC1 becomes sharper as information progresses through the taste system from the first central relay in the brainstem, the nucleus of the solitary tract, via the thalamus to the primary taste cortex in the frontal operculum and insula to reach a secondary cortical taste area in the caudolateral orbitofrontal cortex. 2. Feeding monkeys to satiety with glucose has no effect on the gustatory responses of neurones in the nucleus of the solitary tract, the frontal opercular taste cortex or the insular taste cortex, but decreases the magnitude of the neuronal responses of orbitofrontal cortex taste neurones which respond to glucose to zero. 3. The responses of orbitofrontal cortex taste neurones decrease to foods on which the monkey is fed to satiety, but continue to foods which have not just bee
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