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Whole Organ Model: Multiple Capillaries

By Paul Fitzgerald, Mentor Dr and Anne V. Clough

Abstract

The objective of our work is to develop an understanding of the mechanisms involved in the lung uptake of radiopharmaceuticals that may be useful clinically for evaluating lung injury. A four compartment model to describe the kinetics of Technetium labeled Hexamethylpropyleneamine Oxime ( 99m Tc-HMPAO) in the blood and lung tissue of rats has been developed and implemented in MATLAB. The four partial differential equations of the model are solved using a finite difference approximation to determine the distribution of the four existing species of HMPAO in the blood and lung tissue of rats. Preliminary results demonstrate that this model is capable of fitting the model rate constants to experimentally gathered mass data, which, with further refinement, will allow for the quantification of the difference in the kinetics of 99m Tc-HMPAO in healthy lungs versus diseased lungs

Topics: Sensitivity Analysis
Year: 2013
OAI identifier: oai:CiteSeerX.psu:10.1.1.352.4015
Provided by: CiteSeerX
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