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Improving Protein Secondary-Structure Prediction by Predicting Ends of Secondary-Structure Segments

By Uros Midic, A. Keith Dunker and Zoran Obradovic


Abstract – Motivated by known preferences for certain amino acids in positions around a-helices, we developed neural network-based predictors of both N and C a-helix ends, which achieved about 88 % accuracy. We applied a similar approach for predicting the ends of three types of secondary structure segments. The predictors for the ends of H, E and C segments were then used to create input for protein secondary-structure prediction. By incorporating this new type of input, we significantly improved the basic one-stage predictor of protein secondary structure in terms of both per-residue (Q 3) accuracy (+0.8%) and segment overlap (SOV 3) measure (+1.4). I

Year: 2013
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