Supplementary Table 1: Composition of the simulated 100-genome metagenome. This metagenome contains 400×10 6 101-nucleotide reads. This corresponds to 1 lane of a Illumina HiSeq 2000 flow cell. The reads are paired with a average fragment length of 400 and a standard deviation of 40. The substitution sequencing error rate is 0.25% and uniform. 1 % of the reads are human sequences. The remaining numbers of reads are distributed with a power law (exponent:-0.5). Accession numbers are listed i
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