Copyright © 2010 Daniela Braconi et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Atopic dermatitis and psoriasis are two chronic skin inflammatory diseases that have so far received a greater attention within the scientific community through different post-genomic approaches; on the contrary, acne, which is undoubtedly one of the most common skin disorders involving inflammatory processes, seems to be still quite neglected under the post-genomic point of view. In this paper, we will review how post-genomic technologies have provided new fundamental tools for the analysis of these three conditions and we will cast light on their potential in addressing future research challenges. 1. Skin, Oxidative Stress, and Lipid Peroxidation Skin represents the major interface between the body and the environment; consequently, it is chronically exposed to the harmful action of many chemical/physical toxicants. Besides forming a biological barrier to protect internal organs and systems from the external environment, skin can also symptomatically reflect internal diseases . Bot
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