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DOI 10.1007/s00259-010-1489-y ORIGINAL ARTICLE Biodistribution and radiation dosimetry of 11 C-labelled docetaxel in cancer patients

By Mark Lubberink, M. Lubberink, N. H. Hendrikse, E. F. Smit and W. R. Gerritsen

Abstract

# The Author(s) 2010. This article is published with open access at Springerlink.com Purpose Docetaxel is an important chemotherapeutic agent used for the treatment of several cancer types. As radiolabelled anticancer agents provide a potential means for personalized treatment planning, docetaxel was labelled with the positron emitter 11 C. Non-invasive measurements of [ 11 C]docetaxel uptake in organs and tumours may provide additional information on pharmacokinetics and pharmacodynamics of the drug docetaxel. The purpose of the present study was to determine the biodistribution and radiation absorbed dose of [ 11 C]docetaxel in humans. Methods Biodistribution of [ 11 C]docetaxel was measured in seven patients (five men and two women) with solid tumours using PET/CT. Venous blood samples were A. A. M. van der Veldt (*) : N. H. Hendrikse: M. P. J. Mooijer

Year: 2009
OAI identifier: oai:CiteSeerX.psu:10.1.1.351.974
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