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Beta-Catenin Signaling Negatively Regulates Intermediate Progenitor Population Numbers in the Developing Cortex

By Christopher A. Mutch, Jessica D. Schulte, Eric Olson and Anjen Chenn


Intermediate progenitor cells constitute a second proliferative cell type in the developing mammalian cerebral cortex. Little is known about the factors that govern the production of intermediate progenitors. Although persistent expression of stabilized b-catenin was found to delay the maturation of radial glial progenitors into intermediate progenitors, the relationship between b-catenin signaling and intermediate progenitors remains poorly understood. Using a transgenic reporter mouse for Axin2, a direct target of Wnt/b-catenin signaling, we observed that b-catenin signaling is decreased in intermediate progenitor cells relative to radial glial progenitors. Conditional deletion of b-catenin from mouse cortical neural progenitors increased intermediate progenitor numbers, while conditional expression of stabilized b-catenin reduced the intermediate progenitor population. Together, these findings provide evidence that b-catenin signaling in radia

Year: 2010
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