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Clinical Chemistry 52:7 1247–1253 (2006) Reviews Gc-Globulin: Roles in Response to Injury

By Ursula Meier, Olav Gressner, Frank Lammert and Axel M. Gressner


appears to have important functions in addition to its role as a carrier of vitamin D. Approach: We reviewed recent studies focusing on the pathophysiologic functions and clinical significance of Gc-globulin. Results: Serum concentrations of Gc-globulin, as determined by immunoassay techniques, are decreased in severe injury. The extent of the decrease may have prognostic significance for patient outcomes. Clinical studies and animal models have shown that Gc-globulin has an important role in the clearance of procoagulant actin from the circulation after its release during cell necrosis and tissue injury. Gc-globulin has other potential roles in responses to acute tissue injury through conversion to a macrophage-activating factor

Year: 2005
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