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Comparative proteomic expression profile in all-trans retinoic acid differentiated neuroblastoma cell line

By Flora Cimmino, Daniela Spano, Mario Capasso, Nicola Zambrano, Roberta Russo, Massimo Zollo and Achille Iolascon


Neuroblastoma (NB) is an infant tumor which frequently differentiates into neurons. We used twodimensional differential in-gel electrophoresis (2D-DIGE) to analyze the cytosolic and nuclear protein expression patterns of LAN-5 cells following neuronal differentiating agent all-trans-retinoic acid treatment. We identified several candidate proteins, from which Gβ2 and Prefoldin 3 may have a role on NB development. These results strength the use of proteomics to discover new putative protein targets in cancer. Keywords

Year: 2007
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