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virus-infected cells

By Mitochondrial Distribution, Takayuki Murata, Fumi Goshima, Tohru Daikoku, Kyoko Inagaki-ohara, Hiroki Takakuwa, Keisuke Kato and Yukihiro Nishiyama

Abstract

In this study, mitochondria migrated to a perinuclear region in the cytoplasm in herpes simplex virus (HSV)-infected cells. HSV infection did not promote the expression of cytochrome c oxidase subunit 2 but did promote that of stress-responsive HSP60, both of which are known to be components of mitochondria. The levels of cellular ATP and lactate and mitochondrial membrane potential were maintained for at least 6 h but decreased at the late stage of infection. It was also found that the UL41 and UL46 gene products, both of which are known to be tegument proteins, accumulated in the perinuclear region. The clustering of mitochondria and the accumulation of tegument proteins were completely blocked by the addition of nocodazole an

Year: 2013
OAI identifier: oai:CiteSeerX.psu:10.1.1.322.4329
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