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A molecular marker for centriole maturation in the mammalian cell cycle

By Bodo M. H. Lange and Keith Gull


Abstract. The centriole pair in animals shows duplication and structural maturation at specific cell cycle points. In G1, a cell has two centrioles. One of the centrioles is mature and was generated at least two cell cycles ago. The other centriole was produced in the previous cell cycle and is immature. Both centrioles then nucleate one procentriole each which subsequently elongate to full-length centrioles, usually in S or G2 phase. However, the point in the cell cycle at which maturation of the immature centriole occurs is open to question. Furthermore, the molecular events underlying this process are entirely unknown. Here, using monoclonal and polyclonal antibody approaches, we C ENTRIOLES are a feature of eukaryotic cells that construct cilia or flagella at some time in their life cycle

Year: 1995
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