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Detection of a ventricularspecific myosin heavy chain in adult and developing chicken heart

By Yatian Zhang, Saiyid A. Shafiq and David Bader

Abstract

Abstract. In the present study, a monoclonal antibody (McAb), ALD19, generated against myosin of slow tonic muscle, was shown to react with the heavy chain of ventricular myosin in the adult chicken heart. With this antibody, it was possible to detect a ventricular-specific myosin during myocardial differentiation and to show that the epitope recognized by ALD19 was present from the earliest stages of ventricular differentiation and maintained throughout development only in the ventricle. A second McAb, specific for atrial myosin heavy chain (MHC) (Gonzalez-Sanchez

Topics: myosin heavy chain (MHC) ~ expression in the hearts of
Year: 1986
OAI identifier: oai:CiteSeerX.psu:10.1.1.322.3190
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