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HEPATIC CANALICULAR MEMBRANE 1 The role of mdr2 P-glycoprotein in hepatobiliary lipid transport

By Ronald P. J. Oude Elferink, Guido N. J. Tyfgat, Albert and K. Groen


In the series on the hepatocyte canalicular membrane, this review is the first addressing one of the important canalicular proteins that belong to the superfamily of the ATP-binding cassette (ABC) transporters. These proteins mediate the primary-active ATP-dependent unidirectional transport of substrates across membranes. ABC transporters in the canalicular membrane provide a driving force for bile flow and play a key role in the hepatobiliary elimination of endogenous and Xenobiotic substances. The genes encoding ABC transporters include the multidrug resistance (MDR) genes, and one of them is the murine mdr2 gene. The mdr2 gene product has been identified as a major protein in the hepatocyte canalicular membrane. The function of the mdr2 gene product has been elucidated followin

Year: 2013
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