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Experimental Medicine and Biochemical Sciences,

By Anna T. Palamara, Lucia Nencioni, Katia Aquilano, Giovanna De Chiara, Leyanis Hern, Federico Cozzolino, Maria R. Ciriolo and Enrico Garaci

Abstract

We have previously shown that the life cycles of several viruses are influenced by host-cell redox states. Reports of the antioxidant activities of the plant polyphenol resveratrol (RV) prompted us to investigate its effects on influenza virus replication in vitro and in vivo. We found that RV strongly inhibited the replication of influenza virus in MDCK cells but that this activity was not directly related to glutathione-mediated antioxidant activity. Rather, it involved the blockade of the nuclear-cytoplasmic translocation of viral ribonucleoproteins and reduced expression of late viral proteins seemingly related to the inhibition of protein kinase C activity and its dependent pathways. RV also significantly improved survival and decreased pulmonary viral titers in influenza virus–infected mice. No toxic effects were observed in vitro or in vivo. That RV acts by inhibiting a cellular, rather than a viral, function suggests that it could be a particularly valuable anti-influenza drug. Influenza viruses are enveloped viruses with segmented, single-stranded, negative-sense RNA genomes [1]. Every year, influenza epidemics cause numerous deaths and millions of hospitalizations, but the most frightening effects are seen when new strains of the virus emerge, causing worldwide outbreaks of infection. Recen

Year: 2013
OAI identifier: oai:CiteSeerX.psu:10.1.1.321.7720
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