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Evaluation of the Myocilin (MYOC) Glaucoma Gene in Monkey and Human Steroid-Induced

By Ocular Hypertension, John H. Fingert, Abbot F. Clark, Jamie E. Craig, Wallace L. M. Alward, Grant R. Snibson, Marsha Mclaughlin, Linda Tuttle, David A. Mackey, Val C. Sheffield and Edwin M. Stone


PURPOSE. Glucocorticoid-induced ocular hypertension (the steroid response) may result in optic nerve damage that very closely mimics the pathologic course of primary open angle glaucoma (POAG). In addition, patients with glaucoma and their relatives are much more likely to exhibit the steroid response than unaffected individuals, suggesting a potential link between the steroid response and POAG. Recently, the expression of a gene (MYOC) in the trabecular meshwork was shown to be steroid-induced. MYOC variations thought to be disease-causing also were found in 3 % to 5 % of POAG cases. The purpose of this study was to determine whether some variations in MYOC might be involved in steroid-induced ocular hypertension. METHODS. Seventy human steroid responders and 114 control subjects were screened for variations in the coding sequenc

Year: 2000
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