Location of Repository

Evaluation of the Myocilin (MYOC) Glaucoma Gene in Monkey and Human Steroid-Induced

By Ocular Hypertension, John H. Fingert, Abbot F. Clark, Jamie E. Craig, Wallace L. M. Alward, Grant R. Snibson, Marsha Mclaughlin, Linda Tuttle, David A. Mackey, Val C. Sheffield and Edwin M. Stone

Abstract

PURPOSE. Glucocorticoid-induced ocular hypertension (the steroid response) may result in optic nerve damage that very closely mimics the pathologic course of primary open angle glaucoma (POAG). In addition, patients with glaucoma and their relatives are much more likely to exhibit the steroid response than unaffected individuals, suggesting a potential link between the steroid response and POAG. Recently, the expression of a gene (MYOC) in the trabecular meshwork was shown to be steroid-induced. MYOC variations thought to be disease-causing also were found in 3 % to 5 % of POAG cases. The purpose of this study was to determine whether some variations in MYOC might be involved in steroid-induced ocular hypertension. METHODS. Seventy human steroid responders and 114 control subjects were screened for variations in the coding sequenc

Year: 2000
OAI identifier: oai:CiteSeerX.psu:10.1.1.321.6805
Provided by: CiteSeerX
Download PDF:
Sorry, we are unable to provide the full text but you may find it at the following location(s):
  • http://citeseerx.ist.psu.edu/v... (external link)
  • http://www.iovs.org/content/42... (external link)
  • Suggested articles


    To submit an update or takedown request for this paper, please submit an Update/Correction/Removal Request.