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Running head: Effects of MMPI on LPS-induced Goblet Cell Metaplasia

By On Lps-induced Goblet Cell Metaplasia, Je Hyeong Kim, Sung Yong Lee, Sang Myeon Bak, In Bum Suh, Sang Yeub Lee, Chol Shin, Jae Jeong Shim, Kwang Ho In, Kyung Ho Kang, Se Hwa Yoo, Name Se and Hwa Yoo

Abstract

Bacterial infections of the lung are known to induce inflammatory responses, which lead to mucus hypersecretion. Moreover, mucin synthesis in the airways has been reported to be regulated by neutrophilic inflammation-induced epidermal growth factor receptor (EGFR) expression and its activation. And, matrix metalloproteinases (MMPs), especially MMP-9, have been reported to promote the transmigration of activated neutrophils. In this study, we investigated the associations between lipopolysaccharide(LPS)-induced goblet cell(GC) metaplasia and the EGFR expression and the effects of MMP inhibitor (MMPI). Various concentrations of LPS were instilled into the tracheas of pathogen-free Sprague-Dawley rats, and airways were examined at different times after LPS instillation. To examine the role of MMP-9, rats were treated 3 days before LPS instillation and daily thereafter with MMPI. Neutrophilic infiltration, alcian blue/periodic acid-Schiff(AB/PAS) staining and immunohistochemical staining for MUC5AC, EGFR and MMP-9 were performed

Topics: Copyright &#xa9, 2004 by the American Physiological Society. LCMP-00047-2003.R2
Year: 2013
OAI identifier: oai:CiteSeerX.psu:10.1.1.320.9315
Provided by: CiteSeerX
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