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The periodontal host response with diabetes F USANORI NISHIMURA,YOSHIHIRO IWAMOTO &YOSHIHIKO S OGA In the past decade, periodontal disease has been recognized as not merely a local infectious disease, but as chronic, subclinical, inflammatory disease for the host. Diabetic subjects appear to respond to bacterial challenge in an exaggerated manner as compared with non-diabetic subjects through several possible mechanisms, and develop more severe forms of inflammatory periodontal disease. Severe periodontal disease in such subjects, in turn, acts to reduce insulin sensitivity known as insulin resistance, thereby contributing to the induction of hyperglycemia as well as hyperinsulinemia, importan

Year: 2013
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