Location of Repository

The Antinociceptive Effects of Morphine, Desipramine, and Serotonin and Their Combinations After Intrathecal Injection in the Rat

By Wolfgang Reimann, Harald Schlütz and Norma Selve

Abstract

Antinociception can be produced at the spinal level by activation of opioidergic, noradrenergic, and serotonergic systems. We tested the antinociceptive effects of combined activation of all three systems. Antinociception was assessed in the rat tail-flick test, and drugs were administered via an intrathecal catheter. Morphine, the norepinephrine uptake inhibitor desipramine, and serotonin produced antinociception of their own. The combination of subthreshold doses of morphine 1 �g and of desipramine 3 �g produced pronounced antinociception that was antagonized by yohimbine. The combination of subthreshold morphine with serotonin 50 �g or desipramine with serotonin caused only small antinociceptive effects. When morphine combined with desipramine was decreased to

Year: 2013
OAI identifier: oai:CiteSeerX.psu:10.1.1.320.8288
Provided by: CiteSeerX
Download PDF:
Sorry, we are unable to provide the full text but you may find it at the following location(s):
  • http://citeseerx.ist.psu.edu/v... (external link)
  • http://www.anesthesia-analgesi... (external link)
  • Suggested articles


    To submit an update or takedown request for this paper, please submit an Update/Correction/Removal Request.