A unique human retrovirus (RV) 1 has been consistently isolated from patients with the acquired immune deficiency syndrome (AIDS). Infection of human T lymphocytes or T lymphocyte lines with the AIDS RV can result in a variety of outcomes ranging from rapid cell death to the integration of functionally inert proviral DNAs (1-3). A typical AIDS RV infection is characterized by the appearance of multinucleated cells, a burst of reverse transcriptase (RT) activity, and profound cellular degeneration that extends over a 5-20-d period (1, 4). Two recent reports have described noncytotoxic effects of the AIDS RV on human lymphocytes. In one case (2), PHA-stimulated, IL-2-dependent cultures of helper-inducer human T cells exhibited the characteristic cytopathic effects of acute viral infection, but nonetheless, sufficient numbers of cells survived to continue to produce infectious virus during the 4 mo they were maintained in culture. In the other (3), we described Leu-3- non-virus-producing ceils, derived from a Leu-3 + T cell line, that survived infection with the AIDS RV, and which could be induced with 5-iodo-2'-deoxyuridine (IUdR) to express infectious viru
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