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Protein Markers Characterization of Diabetic Nephropathy by Urinary Proteomic Analysis: Identification of a Processed Ubiquitin Form as a Differentially Excreted Protein in Diabetic Nephropathy Patients

By Hassan Dihazi, Gerhard A. Müller, Ra Lindner, Markus Meyer, Abdul R. Asif, Michael Oellerich and Frank Strutz

Abstract

Previously published online at DOI: 10.1373/clinchem.2007.088260 Background: Identification of markers for prediction of the clinical course of diabetic nephropathy remains a major challenge in disease management. We established a proteomics approach for identification of diabetic nephropathy-related biomarkers in urine. Methods: We used SELDI-TOF mass spectrometry and SAX2 protein arrays to compare protein profiles from urine of 4 defined patient groups. Samples from patients with type 2 diabetes (DM; n � 45) without nephropathy and without microalbuminuria (DM-WNP), patients with DM with macro- or microalbuminuria (DM-NP; n � 38), patients with proteinuria due to nondiabetic renal disease (n � 34), and healthy controls (n � 45) were analyzed. Anionic exchange, reversedphas

Year: 2007
DOI identifier: 10.1373/clinchem.2007.088260
OAI identifier: oai:CiteSeerX.psu:10.1.1.319.5140
Provided by: CiteSeerX
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