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Printed in U.S.A. Effect of Acute Ethanol on Striatal Dopamine Neurotransmission in Ambulatory Rats

By Evgeny A. Budygin, Paul E. M. Phillips, Donita L. Robinson, Andrew P. Kennedy, Raul R. Gainetdinov and R. Mark Wightman


The effect of ethanol on evoked dopamine release in the caudate putamen has been measured in behaving animals with in vivo electrochemistry. Dopamine was measured with fast-scan cyclic voltammetry in adult male rats to resolve the competing processes of dopamine uptake and release. Ethanol dose dependently decreased dopamine efflux compared with salinetreated animals: to 89 % of controls with 0.5 g/kg, 70 % with 1 g/kg, 34 % with 2.5 g/kg, and 18 % with 5 g/kg. This decrease was not due to a change in uptake, as measured by the rate of dopamine disappearance after stimulation, and therefore can be attributed to decreased dopamine release. Additionally, it was not mediated by a decrease in biosynthesis, as measured by L-DOPA accumulation after NSD 1015 administration. The selective dopamine uptake inhibitor GBR 12909 compensate

Year: 2000
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