Angiotensin II (ANG II) is a major stimulator of aldosterone biosynthesis. When investigating the relative contribution of circulating and locally produced ANG II, we were therefore surprised to find that ANG II, given chronically sc (200 ng/kg�min), markedly inhibits a nephrectomy (NX)-induced rise of aldosterone concentrations (from 10 � 2to465 � 90 ng/100 ml in vehicle infused, and from 9 � 2to 177 � 35 in ANG II infused rats 55 h after NX and hemodialysis). We further observed, by in situ hybridization, that bilateral NX increases the number of adrenocortical cells expressing renin and that this rise was prevented by ANG II. Moreover, the rise of aldosterone levels was also inhibited by the AT 1-receptor antagonist, losartan (10 �g/kg�min, THE CIRCULATING renin-angiotensin system (RAS) is a major regulator of aldosterone biosynthesis. To generate angiotensin II (ANG II), kidney-derived renin cleave
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