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0013-7227/02/$15.00/0 The Journal of Clinical Endocrinology & Metabolism 87(2):764–771 Printed in U.S.A. Copyright © 2002 by The Endocrine Society Major Gender Differences in the Lipolytic Capacity of Abdominal Subcutaneous Fat Cells in Obesity Observed b

By Patrik Löfgren, Johan Hoffstedt, Mikael Rydén, Anders Thörne, Cecilia Holm, Hans Wahrenberg and Peter Arner


The influence of obesity on the lipolytic capacity of isolated sc fat cells was studied prospectively in 13 women and 10 men, all obese, but otherwise healthy, before and 2 and 3 yr after weight reduction by bariatric surgery. Nonobese subjects (25 women and 17 men) without a family history of obesity served as the control group. Lipolytic capacity was determined after stimulation at different steps of the lipolytic cascade with noradrenaline, isoprenaline, forskolin, and (Bu) 2AMP. Bariatric surgery was followed by a marked and similar reduction of body mass index and fat cell volume (�40%) in both genders. Before weight loss, lipolytic capacity per cell was elevated in obese women and decreased to normal levels after weight reduction at 2 and 3 yr. However, lipolytic capacity per fat cell HUMANS SHOW CHARACTERISTIC sex-specific differences in the development and distribution of adipos

Year: 2013
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