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Specific Caspase Pathways Are Activated in the Two Stages of Cerebral Infarction

By Ra Benchoua, Christelle Guégan, Cécile Couriaud, Hassan Hosseini, Nathalie Sampaïo, Didier Morin and Brigitte Onténiente


Necrosis and apoptosis have been initially identified as two exclusive pathways for cell death. In acute brain lesions, such as focal ischemia, this binary scheme is challenged by demonstrations of mixed morphological and biochemical characteristics of both apoptosis and necrosis in single cells. The resulting difficulty in defining the nature of cell death that is triggered by severe insults has dramatically impeded the development of therapeutic strategies. We show that in the early stages of cerebral infarction, neurons of the so-called “necrotic ” core display a number of morphological, physiological, and biochemical features of early apoptosis, which include cytoplasmic and nuclear condensations and specific caspase activation cascades. Early activation cascades involve the death receptor pathway linked to caspase-8 and the caspase-1 pathway. They are not associated with alterations of mitochondrial respiratio

Year: 2013
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