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Geometric Characteristics of Dynamic Correlations for Combinatorial Regulation in Gene Expression Noise

By Jiajun Zhang, Zhanjiang Yuan and Tianshou Zhou

Abstract

Knowing which mode of combinatorial regulation (typically, AND or OR logic operation) that a gene employs is important for determining its function in regulatory networks. Here, we introduce a dynamic cross-correlation function between the output of a gene and its upstream regulator concentrations for signatures of combinatorial regulation in gene expression noise. We find that the correlation function is always upwards convex for the AND operation whereas downwards convex for the OR operation, whichever sources of noise (intrinsic or extrinsic or both). In turn, this fact implies a means for inferring regulatory synergies from available experimental data. The extensions and applications are discussed. PACS numbers: 87.18.-h, 05.45.Tp, 87.16.Yc Cells live in a complex environment and continuously have to make decisions for different signals that they sense. A challenge in systems biology is to understand how signals are integrated. As the central informationprocessing units of living cells, transcription regulatory networks allow them to integrate different signals an

Year: 2009
DOI identifier: 10.1103/physreve.80.021905
OAI identifier: oai:CiteSeerX.psu:10.1.1.314.5777
Provided by: CiteSeerX
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