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By K. Jadwani and I. Intrgduction


Surgical sterilisation is one of the most important methods of fertility control in India. There is a need to study non-surgical methods of tubal occlusion. Several chemical agents are presently being tried in experimental animals but only a few can be used in humans. The ideal chemical should be effective, inexpensive, easily available and easy to administer. Most chemicals used for sterilisation are either sclerosing agents which act by destroying the inner lining of the fallopian tube and causing subsequent fibrosis or agents which solidify within the tube and act by forming a plug and bringing about tissue adhesiveness. Drugs such as ethanol, fomaldehyde and silver nitrate cause tubal acclusion but cannot be used because of their toxicity. Silastic S. 5392, S. 521 and inethyle-’ 2-cyanoacrylate (M.C.A.) act by causing tissue adhesiveness. They are highly effective but the process of application has not, so far, been established for these chemicals. In 1961, Zipper first used quinacrine for blocking the tubal lumen. Quinacrine was used in 800 women; 638 study subjects were observed for 14,677 women months

Year: 2013
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