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THE JOURNAL OF CELL BIOLOGY

By Rose Loughlin, Rebecca Heald and François Nédélec

Abstract

The metaphase spindle is a dynamic bipolar structure crucial for proper chromosome segregation, but how microtubules (MTs) are organized within the bipolar architecture remains controversial. To explore MT organization along the pole-to-pole axis, we simulated meiotic spindle assembly in two dimensions using dynamic MTs, a MT cross-linking force, and a kinesin-5–like motor. The bipolar structures that form consist of antiparallel fluxing MTs, but spindle pole formation requires the addition of a NuMA-like minus-end cross-linker an

Year: 2013
OAI identifier: oai:CiteSeerX.psu:10.1.1.292.5153
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