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Effect of shear force on the separation of double stranded DNA

By Rakesh Kumar Mishra, Garima Mishra, M. S. Li and Sanjay Kumar

Abstract

Using the Langevin Dynamics simulation, we have studied the effects of the shear force on the rupture of short double stranded DNA at different temperatures. We show that the rupture force increases linearly with the chain length and approaches to the asymptotic value in accordance with the experiment. The qualitative nature of these curves almost remains same for different temperatures but with a shift in the force. We observe three different regimes in the extension of covalent bonds (back bone) under the shear force.Comment: 4 pages, 4 figure

Topics: Condensed Matter - Soft Condensed Matter, Physics - Biological Physics
Year: 2012
DOI identifier: 10.1103/PhysRevE.84.032903
OAI identifier: oai:arXiv.org:1104.3059
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