The inclusion of physical effects from sea quarks has been one of the main advances in lattice QCD simulations over the last few years. We report on recent studies with four flavours of dynamical quarks and address some of the potential issues arising in this new setup. First results for physical observables in the light, strange and charm sectors are presented together with the status of dedicated simulations to perform the non-perturbative renormalisation in mass-independent schemes.Comment: 15 pages, 14 figures. Plenary talk at the XXVIII International Symposium on Lattice Field Theory, Lattice2010, June 14-19, 2010, Villasimius, Ital
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