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Research | Children’s Health Road Traffic and Childhood Leukemia: The ESCALE Study (SFCE)

By Alicia Amigou, Claire Sermage-faure, Laurent Orsi, Guy Leverger, André Baruchel, Yves Bertr and Pierre Bordigoni Denis Hémon


Ba c k g ro u n d: Traffic is a source of environmental exposures, including benzene, which may be related to childhood leukemia. Objectives: A national registry–based case–control study [ESCALE (Etude Sur les Cancers et les Leucémies de l’Enfant, Study on Environmental and Genetic Risk Factors of Childhood Cancers and Leukemia)] carried out in France was used to assess the effect of exposure to road traffic exhaust fumes on the risk of childhood leukemia. Me t h o d s: Over the study period, 2003–2004, 763 cases and 1,681 controls < 15 years old were included, and the controls were frequency matched with the cases on age and sex. The ESCALE data were collected by a standardized telephone interview of the mothers. Various indicators of exposure to traffic and pollution were determined using the geocoded addresses at the time of diagnosis for the cases and of interview for the controls. Indicators of the distance from, and density of, main roads and traffic nitrogen dioxide (NO2) concentrations derived from traffic emission data were used. Odds ratios (ORs) were estimated using unconditional regression models adjusted for potential confounders

Year: 2011
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