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World Academy of Science, Engineering and Technology 39 2008 Predicting Protein Function using Decision Tree

By Manpreet Singh, Parminder Kaur Wadhwa and Surinder Kaur


Abstract—The drug discovery process starts with protein identification because proteins are responsible for many functions required for maintenance of life. Protein identification further needs determination of protein function. Proposed method develops a classifier for human protein function prediction. The model uses decision tree for classification process. The protein function is predicted on the basis of matched sequence derived features per each protein function. The research work includes the development of a tool which determines sequence derived features by analyzing different parameters. The other sequence derived features are determined using various web based tools. Keywords—Sequence Derived Features, decision tree. I. PROTEINS AND THEIR ROLE ROTEINS are the primary components of living things, P and they play many roles. Proteins are the molecular machinery that regulates and executes nearly every biological function [4]. Proteins provide structural support and the infrastructure that holds a creature together; they are enzymes that make the chemical reactions necessary for life possible; they are the switches that control whether genes are turned on or off; they are the sensors that see and taste and smell, and the effectors that make muscles move; they are the detectors that distinguish self from oneself and create an immune response. Proteins have a variety of roles that they must fulfill: • They are the enzymes that rearrange chemical bonds. • They carry signals to and from the outside of the cell, and within the cell. • They transport small molecules. • They form many of the cellular structures. • They regulate cell processes, turning them on and off and controlling their rates. Despite their radical differences in function, all proteins are made of the same basic constituents: the amino acids. Each amino acid shares a basic structure, consisting of a central carbon atom (C), an amino group (NH3) at one end, a carboxyl group (COOH) at the other, and a variable side chai

Year: 2011
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