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Finer Discrimination of Fiber Orientation at High q Diffusion MR: Theoretical and Experimental Confirmation

By L. Avram, Y. Assaf, P. J. Basser and Y. Cohen

Abstract

Recently, it was found that the signal attenuation observed in diffusion MR experiments of a pack of cylindrical impermeable microcapillary tubes have high directional sensitivity. We have modeled this signal decay as a function of q using the restricted component of the newly proposed CHARMED model, which describes intra-axonal diffusion. CHARMED fits the data nicely, and more importantly predicts the high sensitivity of the diffraction pattern on the tube orientation. These findings suggest that high q diffusion imaging has the potential to better resolve directional characteristics of white matter as compared to DTI or other low q diffusion imaging methods

Year: 2005
OAI identifier: oai:CiteSeerX.psu:10.1.1.192.4679
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