Abstract. We provide an effective uniform upper bond for the number of zeros of the first non-vanishing Melnikov function of a polynomial perturbations of a planar polynomial Hamiltonian vector field. The bound depends on degrees of the field and of the perturbation, and on the order k of the Melnikov function. The generic case k = 1 was considered by Binyamini, Novikov and Yakovenko ( [BNY10]). The bound follows from an effective construction of the Gauss-Manin connection for iterated integrals
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