To determine resistance of highly pathogenic avian infl uenza (H5N1) virus to chlorination, we exposed allantoic fl uid containing 2 virus strains to chlorinated buffer at pH 7 and 8, at 5°C. Free chlorine concentrations typically used in drinking water treatment are sufficient to inactivate the virus by>3 orders of magnitude. Growing concerns about the public health threat posed by highly pathogenic avian influenza (HPAI) subtype H5N1 has prompted interest in evaluating environmental control measures for this virus. The World Health Organization has noted that more information is needed on the effectiveness of inactivation of subtype H5N1 in water (1). Since 2002, HPAI (H5N1) has been reportedly isolated from>50 different wild avian species, mainly aquatic birds in the order Anseriformes (2). Experimentally infected waterfow
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