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R EPORTS Interlocked Feedback Loops Within the Drosophila Circadian Oscillator

By Nick R. J. Glossop, Lisa C. Lyons and Paul E. Hardin

Abstract

Drosophila Clock (dClk) is rhythmically expressed, with peaks in mRNA and protein (dCLK) abundance early in the morning. dClk mRNA cycling is shown here to be regulated by PERIOD-TIMELESS (PER-TIM)–mediated release of dCLKand CYCLE (CYC)–dependent repression. Lack of both PER-TIM derepression and dCLK-CYC repression results in high levels of dClk mRNA, which implies that a separate dClk activator is present. These results demonstrate that the Drosophila circadian feedback loop is composed of two interlocked negative feedback loops: a per-tim loop, which is activated by dCLK-CYC and repressed by PER-TIM, and a dClk loop, which is repressed by dCLK-CYC and derepressed by PER-TIM. The circadian oscillators of eukaryotic and certain prokaryotic organisms are controlled through autoregulatory feedback loops in gene expression (1). In Drosophila, five genes have been identified that are necessary for circadian feedback loop function: period (per), timeles

Topics: tim, Drosophila Clock (dClk, Cycle (Cyc
Year: 2010
OAI identifier: oai:CiteSeerX.psu:10.1.1.160.5671
Provided by: CiteSeerX
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