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A Clinical Comparison of Propanidid and Thiopentone as Induction Agents to General Anaesthesia

By J. E. Wynands, G. S. Fox and F. R. C. P. (c)f


PROPANIDID, an ultra short-acting non-barbiturate compound, has been successfully used as an intravenous anaesthetic agent. 1- 5 Dundee and Clarke have compared thiopentone, propanidid, G29505, and methohexitone as intravenous agents. 4 The purpose of this investigation was to compare thiopentone and propanidid as induction agents for short operative procedures. METHOD Two hundred patients undergoing cystoscopy, with or without retrograde pyelogram, were studied. Half of the patients received 2.5 per cent thiopentone as an induction agent, the remainder received 5 per cent propanidid. On arrival in the operating room, the patients were given atropine 0.4 mg. intravenously. No other premedicant drugs were administered, nor were the patients receiving medications for other reasons. When an increase in pulse rate occurred, the patients were induced with either propanidid or thiopentone. If a rise in pulse rate was not obtained, the patients were induced two minutes after the intravenous injection of the atropine. Maintenance of anaesthesia was wit

Year: 1966
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