Abstract. This paper presents a methodology to formulate natural language rules for an adaptive neuro-fuzzy system based on discovered knowledge, supported by prior knowledge and statistical modeling. These rules could be improved using statistical methods and neural nets. This gives clinicians a valuable tool to explore the importance of different variables and their relations in a disease and could aid treatment selection. A prototype using the proposed methodology has been used to induce an Adaptive Neuro Fuzzy Inference Model that has been used to “discover ” relationships between fluctuation, treatment and disease severity in Parkinson. Preliminary results from this project are promising and show that Neuro-fuzzy techniques in combination with statistical methods may offer medical research and medical applications a useful combination of methods.
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