Skip to main content
Article thumbnail
Location of Repository

Trajectory Clustering: A Non-Parametric Method for Grouping Gene Expression Time

By T. L. Phang, M. C. Neville, M. Rudolph and L. HunterT. L. Phang, M. C. Neville, M. Rudolph and L. Hunter

Abstract

Trajectory clustering is a novel and statistically well-founded method for clustering time series data from gene expression arrays. Trajectory clustering uses non-parametric statistics and is hence not sensitive to the particular distributions underlying gene expression data. Each cluster is clearly defined in terms of direction of change of expression for successive time points (its 'trajectory'), and therefore has easily appreciated biological meaning. Applying the method to a dataset from mouse mammary gland development, we demonstrate that it produces different clusters than Hierarchical, K-means, and Jackknife clustering methods, even when those methods are applied to differences between successive time points. Compared to all of the other methods, trajectory clustering was better able to match a manual clustering by a domain expert, and was better able to cluster groups of genes with known related functions.

Year: 2003
OAI identifier: oai:CiteSeerX.psu:10.1.1.135.5283
Provided by: CiteSeerX
Download PDF:
Sorry, we are unable to provide the full text but you may find it at the following location(s):
  • http://citeseerx.ist.psu.edu/v... (external link)
  • http://helix-web.stanford.edu/... (external link)
  • Suggested articles


    To submit an update or takedown request for this paper, please submit an Update/Correction/Removal Request.