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Chemometric Evaluation of Pharmaceutical Properties of Antipyrine Granules by Near-Infrared Spectroscopy

By Makoto Otsuka, Yoshifumi Mouri and Yoshihisa Matsuda


The purpose of this research was to apply near-infrared (NIR) spectroscopy with chemometrics to predict the change of pharmaceutical properties of antipyrine granules during granulation by regulation of the amount of water added. The various kinds of granules (mean particle size, 70-750 µm) were obtained from the powder mixture (1 g of antipyrine, 6 g of hydroxypropylcellulose, 140 g of lactose, and 60 g of potato starch) by regulation of the added water amount (11-19 wt/wt%) in a high-speed mixer. The granules were characterized by mean particle size, angle of repose, compressibility, tablet porosity, and tablet hardness as parameters of pharmaceutical properties. To predict the pharmaceutical properties, NIR spectra o

Topics: agitating granulation, physical properties, near-infrared spectroscopy
Year: 2002
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