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BIOINFORMATICS Model-Based Bayesian Clustering (MBBC)

By Yongsung Joo, James G. Booth and Younghwan Namkoong


Motivation: The program MBBC 2.0 clusters time course microarray data using a Bayesian product partition model (Booth et al. 2007). Results: The Bayesian product partition model in Booth et al. (2007) simultaneously searches for the optimal number of clusters, and assigns cluster memberships based on temporal changes of gene expressions. MBBC 2.0 to makes this method easily available for statisticians and scientists, and is built with three free computer language software packages: Ox, R, and C++, taking advantage of the strengths of each language. Within MBBC, the search algorithm is implemented with Ox and resulting graphs are drawn with R. A user-friendly graphical interface is built with C++ to run the Ox and R programs internally. Thus, MBBC users are not required to know how to useOx,R, orC++, but they must be pre-installed. Availability: A self-extractable zip file, MBBC20zip.exe, is available at the MBBC webpage∼casella/mbbc/, which contains MBBC.exe, source files, and all other related files. The current version works only in Windows operating system. A free installation program and overview for Ox is available at A detailed installation guide for Ox is provided by MBBC, and is accessible without installing Ox. R is available at Contact

Year: 2009
OAI identifier: oai:CiteSeerX.psu:
Provided by: CiteSeerX
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