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JCB Report Numb Is an Endocytic Protein

By Elisa Santolini and Claudia Puri

Abstract

Abstract. Numb is a protein that in Drosophila determines cell fate as a result of its asymmetric partitioning at mitosis. The function of Numb has been linked to its ability to bind and to biologically antagonize Notch, a membrane receptor that also specifies cell fate. The biochemical mechanisms underlying the action of Numb, however, are still largely unknown. The wide pattern of expression of Numb suggests a general function in cellular homeostasis that could be additional to, or part of, its action in fate determination. Such a function could be endocytosis, as suggested by the interaction of Numb with Eps15, a component of the endocytic machinery.

Publisher: 2008-12-31
Year: 2008
OAI identifier: oai:CiteSeerX.psu:10.1.1.134.44
Provided by: CiteSeerX
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