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Choroidal Round Hyporeflectivities in Geographic Atrophy

By Corbelli Eleonora, Sacconi Riccardo, De Vitis Luigi Antonio, Carnevali Adriano, Rabiolo Alessandro, Querques Lea, Bandello Francesco and Querques Giuseppe


In geographic atrophy (GA), choroidal vessels typically appear on structural optical coherence tomography (OCT) as hyperreflective round areas with highly reflective borders. We observed that some GA eyes show choroidal round hyporeflectivities with highly reflective borders beneath the atrophy, and futher investigated the charcteristcs by comparing structural OCT, indocyanine green angiography (ICGA) and OCT angiography (OCT-A).Round hyporeflectivities were individuated from a pool of patients with GA secondary to non-neovascular age-related macular degeneration consecutively presenting between October 2015 and March 2016 at the Medical Retina & Imaging Unit of the University Vita-Salute San Raffaele. Patients underwent a complete ophthalmologic examination including ICGA, structural OCT and OCT-A. The correspondence between choroidal round hyporeflectivities beneath GA on structural OCT and ICGA and OCT-A imaging were analyzed., respectively; p = 0.01).Our results suggest that most round hyporeflectivities beneath GA may represent non-perfused or hypo-perfused choroidal vessels with non-detectable flow

Publisher: Public Library of Science
Year: 2016
DOI identifier: 10.1371/journal.pone.0166968
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