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Infection in Ugandan Men Is Associated with Increased Abundance and Function of HIV Target Cells in Blood, but Not the Foreskin: A Cross-sectional Study

By Prodger Jessica L., Ssemaganda Aloysious, Ssetaala Ali, Kitandwe Paul K., Muyanja Enoch, Mpendo Juliet, Nanvubya Annet, Wambuzi Mathias, Nielsen Leslie, Kiwanuka Noah and Kaul Rupert

Abstract

infection has been associated with an increased HIV prevalence in humans and SHIV incidence in primate models. We hypothesized that immune activation from this gastrointestinal mucosa infection would increase highly HIV-susceptible CD4 T cell subsets in the blood and the foreskin through common mucosal homing.-infected men demonstrated enhanced function (28.1 vs. 16.3% producing multiple cytokines, p = 0.046). However, these immune alterations were not observed in foreskin tissue. induced changes in T cell immunology mediated through the common mucosal immune system are not likely to increase HIV susceptibility in the foreskin

Publisher: Public Library of Science
Year: 2015
DOI identifier: 10.1371/journal.pntd.0004067
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