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The Stroke Oxygen Pilot Study: A Randomized Controlled Trial of the Effects of Routine Oxygen Supplementation Early after Acute Stroke—Effect on Key Outcomes at Six Months

By Ali Khalid, Warusevitane Anushka, Lally Frank, Sim Julius, Sills Sheila, Pountain Sarah, Nevatte Tracy, Allen Martin and Roffe Christine


Post-stroke hypoxia is common, and may adversely affect outcome. We have recently shown that oxygen supplementation may improve early neurological recovery. Here, we report the six-month outcomes of this pilot study.≤0.05. = 0.86). The mean differences in the ability to perform basic (Barthel Index) and extended activities of daily living (NEADL), and quality of life (EuroQol) were also non-significant.None of the key outcomes differed at 6 months between the groups. Although not statistically significant and generally of small magnitude, the effects were predominantly in favour of the oxygen group; a larger trial, powered to show differences in longer-term functional outcomes, is now on-going

Publisher: Public Library of Science
Year: 2013
DOI identifier: 10.1371/journal.pone.0059274
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