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Clofibrate-inducible, 28-kDa peroxisomal integral membrane protein is encoded by PEX11

By Isao Abe, Kanji Okumoto, Shigehiko Tamura and Yukio Fujiki

Abstract

AbstractWe cloned a human PEX11 cDNA by expressed sequence tag homology search using yeast Candida boidinii PEX11, followed by screening of human liver cDNA library. PEX11 encoded a peroxisomal protein Pex11p comprising 247 amino acids, with two transmembrane segments and a dilysine motif at the C-terminus. Pex11p comigrated in SDS-PAGE with a 28-kDa peroxisomal integral membrane protein (PMP28) isolated from the liver of clofibrate-treated rats and was crossreactive to anti-PMP28 antibody, thereby indicating PEX11 to encode PMP28. Pex11p exposes both N- and C-terminal parts to the cytosol. PEX11 was not responsible for ten complementation groups of human peroxisome deficiency disorders

Publisher: Federation of European Biochemical Societies. Published by Elsevier B.V.
Year: 1998
DOI identifier: 10.1016/S0014-5793(98)00815-1
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