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Origin and Dynamics of HIV-1 Subtype C Infection in India

By Shen Chengli, Craigo Jodi, Ding Ming, Chen Yue and Gupta Phalguni

Abstract

To investigate the geographical origin and evolution dynamics of HIV-1 subtype C infection in India. gp120 sequences with known sampling year (from 1991 to 2008) were employed to determine the origin of HIV infection in India. sequences was used to investigate the geographical origin and tMRCA of Indian HIV-1 subtype C. Evolutionary parameters including origin date and demographic growth patterns of Indian subtype C were estimated using a Bayesian coalescent-based approach under relaxed molecular clock models.The majority of the analyzed Indian and South African HIV-1 subtype C sequences formed a single monophyletic cluster. The most recent common ancestor date was calculated to be 1975.56 (95% HPD, 1968.78–1981.52). Reconstruction of the effective population size revealed three phases of epidemic growth: an initial slow growth, followed by exponential growth, and then a plateau phase approaching present time. Stabilization of the epidemic growth phase correlated with the foundation of National AIDS Control Organization in India.Indian subtype C originated from a single South African lineage in the middle of 1970s. The current study emphasizes not only the utility of HIV-1 sequence data for epidemiological studies but more notably highlights the effectiveness of community or government intervention strategies in controlling the trend of the epidemic

Publisher: Public Library of Science
Year: 2011
DOI identifier: 10.1371/journal.pone.0025956
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