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Explore the Features of Brain-Derived Neurotrophic Factor in Mood Disorders

By Yeh Fan-Chi, Kao Chung-Feng and Kuo Po-Hsiu


from the perspective of various aspects of systems biology, including its molecular evolution, genomic studies, protein functions, and pathway analysis. and performed pathway-based analysis using large genome-wide association (GWA) datasets obtained for mood disorders. and mood disorders were not significant in most of the genomic studies (e.g., linkage, association, gene expression, GWA), while relationships between serum/plasma BDNF level and mood disorders were consistently reported. Pro-BDNF is important in the response to stress; the literature review suggests the necessity of studying both pro- and m-BDNF with regard to mood disorders. In addition to conventional pathway analysis, we further considered proteins that interact with BDNF (I-Genes) and identified several biological pathways involved with BDNF or I-Genes to be significantly associated with mood disorders.Systematically examining the features and biological pathways of BDNF may provide opportunities to deepen our understanding of the mechanisms underlying mood disorders

Publisher: Public Library of Science
Year: 2015
DOI identifier: 10.1371/journal.pone.0128605
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