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Integrated Analyses of microRNAs Demonstrate Their Widespread Influence on Gene Expression in High-Grade Serous Ovarian Carcinoma

By Creighton Chad J., Hernandez-Herrera Anadulce, Jacobsen Anders, Levine Douglas A., Mankoo Parminder, Schultz Nikolaus, Du Ying, Zhang Yiqun, Larsson Erik, Sheridan Robert, Xiao Weimin, Spellman Paul T., Getz Gad, Wheeler David A., Perou Charles M., Gibbs Richard A., Sander Chris, Hayes D. Neil and Gunaratne Preethi H.

Abstract

The Cancer Genome Atlas (TCGA) Network recently comprehensively catalogued the molecular aberrations in 487 high-grade serous ovarian cancers, with much remaining to be elucidated regarding the microRNAs (miRNAs). Here, using TCGA ovarian data, we surveyed the miRNAs, in the context of their predicted gene targets.) and substantially decreased ovarian cancer cell viability.This study establishes miRNAs as having a widespread impact on gene expression programs in ovarian cancer, further strengthening our understanding of miRNA biology as it applies to human cancer. As with gene transcripts, miRNAs exhibit high diversity reflecting the genomic heterogeneity within a clinically homogeneous disease population. Putative miRNA:mRNA interactions, as identified using integrative analysis, can be validated. TCGA data are a valuable resource for the identification of novel tumor suppressive miRNAs in ovarian as well as other cancers

Publisher: Public Library of Science
Year: 2012
DOI identifier: 10.1371/journal.pone.0034546
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