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MafB is a critical regulator of complement component C1q

By Mai Thi Nhu Tran, Michito Hamada, Hyojung Jeon, Risako Shiraishi, Keigo Asano, Motochika Hattori, Megumi Nakamura, Yuki Imamura, Yuki Tsunakawa, Risa Fujii, Toshiaki Usui, Kaushalya Kulathunga, Christina-Sylvia Andrea, Ryusuke Koshida, Risa Kamei, Yurina Matsunaga, Makoto Kobayashi, Hisashi Oishi, Takashi Kudo and Satoru Takahashi

Abstract

Complement component C1q activates efferocytosis, suppresses inflammatory responses, and is thereby thought to limit autoimmune disease. Here, the authors show that macrophage transcription factor MafB regulates total serum levels of C1q, which contributes to preventing autoimmune disease in mice

Topics: Science, Q
Publisher: Nature Publishing Group
Year: 2017
DOI identifier: 10.1038/s41467-017-01711-0
OAI identifier: oai:doaj.org/article:9f34d6d71d0a49eaac0a0cac78b32c5c
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